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Sucking ice chips for half an hour around a bolus dose of fluorouracil or high-dose melphalan roughly halves the risk of painful mouth ulcers. It costs nothing and is recommended in international mucositis guidelines.
Cooling the mouth constricts mucosal blood vessels during the short window when a bolus cytotoxic is at peak concentration, reducing the dose delivered to the oral epithelium. A 2015 Cochrane review of 14 randomised trials found that oral cryotherapy reduces the incidence of oral mucositis of any severity and of moderate to severe mucositis in adults receiving fluorouracil-based chemotherapy for solid cancers, and probably reduces it with high-dose melphalan before stem cell transplant. The 2020 MASCC/ISOO guidelines recommend 30 minutes of oral cryotherapy for patients receiving bolus 5-fluorouracil and for high-dose melphalan conditioning. It does not help with infusional 5-FU or capecitabine, whose exposure is prolonged. It is uncomfortable for some and unsuitable with oxaliplatin because cold triggers acute neuropathy.
Local vasoconstriction lowers drug delivery to the oral mucosa during the peak plasma phase of short-half-life cytotoxics.
Four technology pages on OnCo cite this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing pages listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One technology page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
Query for this technology: (TITLE:"Oral cryotherapy ice chips to prevent mucositis" OR ABSTRACT:"Oral cryotherapy ice chips to prevent mucositis") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Oral cryotherapy (ice chips) to prevent mucositis, not a curated reading list.
Shares MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy, Mucositis and stomatitis, Multinational Association of Supportive Care in Cancer, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Multinational Association of Supportive Care in Cancer, Toxicity and quality of life are undervalued, Cytotoxic chemotherapy and the tags complementary, supportive-care.
Shares Scalp cooling (cold caps: DigniCap, Paxman), Toxicity and quality of life are undervalued, Cytotoxic chemotherapy and the tags complementary, supportive-care.
Shares Dry mouth, teeth and taste after head and neck radiotherapy, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Scalp cooling (cold caps: DigniCap, Paxman), Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Photobiomodulation (low-level laser) for oral mucositis, Multinational Association of Supportive Care in Cancer, Scalp cooling (cold caps: DigniCap, Paxman), Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Scalp cooling (cold caps: DigniCap, Paxman), Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Dry mouth, teeth and taste after head and neck radiotherapy and the tags complementary, supportive-care.