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Wearing frozen gloves and socks, or tight surgical gloves, during taxane infusions reduces nail damage and may reduce numbness in the hands and feet, by narrowing the blood vessels while the drug is at its peak. Trials are small but consistent, and it is cheap.
The same principle as scalp cooling applies to hands and feet: reducing blood flow while docetaxel or paclitaxel is at peak concentration reduces delivery to nail beds and peripheral nerves. A multicentre study of frozen gloves during docetaxel showed markedly less nail toxicity on the gloved hand than the ungloved control hand, and a self-controlled study of 36 women receiving weekly paclitaxel (Hanai et al., JNCI 2018) found lower rates of objective and subjective neuropathy on the frozen-glove and sock side. Randomised trials of compression therapy with tight surgical gloves report similar protection with better comfort, and trials comparing cooling, compression and both are ongoing. The 2022 SIO-ASCO pain guideline notes cryotherapy or compression may be offered for chemotherapy-induced neuropathy prevention with low certainty. Frostbite is a risk with prolonged contact; oxaliplatin is a contraindication to cold.
Vasoconstriction lowers local drug delivery to nail matrix and peripheral nerve during the short infusion peak of taxanes.
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Shares Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology-ASCO Guideline, Peripheral neuropathy (chemotherapy-induced), Nerve damage from chemotherapy: what recovers, and what helps, Docetaxel and the tags complementary, supportive-care.
Shares Peripheral neuropathy (chemotherapy-induced), Nerve damage from chemotherapy: what recovers, and what helps, Paclitaxel / nab-paclitaxel, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Scalp cooling (cold caps: DigniCap, Paxman), Docetaxel, Paclitaxel / nab-paclitaxel, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology-ASCO Guideline, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology-ASCO Guideline, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology-ASCO Guideline, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology-ASCO Guideline, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology-ASCO Guideline, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.