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Shining low-power red or near-infrared light on the inside of the mouth before and during treatment prevents severe mouth ulcers in people having head and neck radiotherapy or high-dose chemotherapy for transplant. Mucositis guidelines recommend it, though few centres yet have the equipment.
Photobiomodulation delivers non-thermal red or near-infrared light (typically 630-680 nm or 780-830 nm) to oral mucosa, stimulating mitochondrial cytochrome c oxidase, reducing inflammatory signalling and speeding epithelial repair. Randomised trials in haematopoietic stem cell transplantation and in head and neck chemoradiation consistently show lower incidence and severity of grade 3-4 oral mucositis, less pain and fewer feeding-tube placements. The 2019 MASCC/ISOO systematic review and 2020 guidelines recommend intraoral photobiomodulation for prevention of oral mucositis in both settings, with specified device parameters. It is painless and quick but requires daily attendance and a trained operator; the theoretical concern of stimulating residual tumour has not been borne out in follow-up of irradiated patients.
Photon absorption by mitochondrial chromophores raises ATP production and modulates reactive oxygen species and NF-kB signalling, reducing inflammation and promoting healing.
Four technology pages on OnCo cite this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing pages listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One technology page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
Query for this technology: (TITLE:"Photobiomodulation low-level laser for oral mucositis" OR ABSTRACT:"Photobiomodulation low-level laser for oral mucositis") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Photobiomodulation (low-level laser) for oral mucositis, not a curated reading list.
Shares MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy, Mucositis and stomatitis, Multinational Association of Supportive Care in Cancer, Evidence-based integrative oncology and the tags complementary, supportive-care.
Shares Dry mouth, teeth and taste after head and neck radiotherapy, Evidence-based integrative oncology, Toxicity and quality of life are undervalued, Head and neck squamous cell carcinoma and the tags complementary, supportive-care.
Shares Skin during and after radiotherapy: dressings, steroids and what lasts, Dry mouth, teeth and taste after head and neck radiotherapy, Evidence-based integrative oncology, Head and neck squamous cell carcinoma and the tags complementary, supportive-care.
Shares Multinational Association of Supportive Care in Cancer, Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.