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Ginger capsules taken alongside standard anti-sickness drugs reduced nausea in the largest randomised trial, but other trials found no effect and the doses and products vary. It is safe for most people, with a caution about bleeding for anyone on anticoagulants.
Ginger (Zingiber officinale) has antiemetic activity attributed to gingerols and shogaols acting on 5-HT3 and other gut receptors. In a randomised placebo-controlled trial of 576 patients (Ryan et al., Supportive Care in Cancer 2012), 0.5 g or 1 g of ginger daily for six days starting three days before chemotherapy, added to 5-HT3 antagonists, reduced acute nausea severity; higher doses did not, and vomiting was unaffected. Several other randomised trials were negative or too small, and systematic reviews describe the evidence as mixed. Ginger is not part of MASCC/ESMO or ASCO antiemetic guidelines. Ginger has mild antiplatelet effects, so caution is advised with anticoagulants and before surgery; products are unstandardised.
Gingerols and shogaols antagonise 5-HT3 receptors, accelerate gastric emptying and may act on NK1 signalling, targets shared with prescription antiemetics.
Query for this technology: (TITLE:"Ginger for chemotherapy nausea" OR ABSTRACT:"Ginger for chemotherapy nausea") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Ginger for chemotherapy nausea, not a curated reading list.
Shares Antiemetics for chemotherapy-induced nausea and vomiting, Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Antiemetics for chemotherapy-induced nausea and vomiting, Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.
Shares Evidence-based integrative oncology, Toxicity and quality of life are undervalued and the tags complementary, supportive-care.