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Chemotherapy doses are calculated from height and weight, a formula from the 1950s. Doses based on actual muscle mass may cause fewer severe side-effects.
Body surface area poorly predicts clearance for most cytotoxics, and low lean body mass is associated with markedly higher rates of severe toxicity at standard doses, above all with fluoropyrimidines and taxanes. Lean mass is now measurable automatically from routine imaging, making an alternative dosing metric practical for the first time.
Shares Definition and classification of cancer cachexia: an international consensus, Sarcopenia, Cachexia, toxicity and the limits of the patient, AI in radiology.
Shares Chemotherapy roadmap: mustard gas → curative combinations → the warhead inside smarter drugs, Wrong doses, Toxicity and quality of life are undervalued, Cytotoxic chemotherapy.
Shares Chemotherapy roadmap: mustard gas → curative combinations → the warhead inside smarter drugs, Paclitaxel / nab-paclitaxel, Toxicity and quality of life are undervalued, HR-positive / HER2-negative breast cancer.
Shares Definition and classification of cancer cachexia: an international consensus, Cachexia, toxicity and the limits of the patient, Toxicity and quality of life are undervalued.
Shares Docetaxel, Paclitaxel / nab-paclitaxel, Toxicity and quality of life are undervalued, HR-positive / HER2-negative breast cancer.
Shares Docetaxel, Paclitaxel / nab-paclitaxel, Toxicity and quality of life are undervalued, Cytotoxic chemotherapy.
Shares Docetaxel, Paclitaxel / nab-paclitaxel, Toxicity and quality of life are undervalued, HR-positive / HER2-negative breast cancer.
Shares Definition and classification of cancer cachexia: an international consensus, Cachexia, toxicity and the limits of the patient, Toxicity and quality of life are undervalued.