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Removing an amino acid or nutrient that certain tumours cannot make for themselves, while normal cells can.
Arginine deprivation with pegargiminase (ADI-PEG 20) exploits ASS1 loss; the phase 2/3 ATOMIC-Meso study in mesothelioma completed (NCT02709512), while the phase 3 leiomyosarcoma study (NCT05712694) and a lung study were terminated. Glutaminase inhibition failed in renal cancer, asparaginase remains standard in ALL, and dietary approaches such as ketogenic or fasting-mimicking regimens have only small randomised trials with mixed results. The lesson so far is that metabolic dependencies are real but narrow.
Enzymatic depletion of a circulating nutrient (arginine, asparagine, methionine) kills tumour cells that have lost the biosynthetic enzyme, while normal cells resynthesise it.
Query for this technology: (TITLE:"Metabolic therapy: starving the tumour of a nutrient" OR ABSTRACT:"Metabolic therapy: starving the tumour of a nutrient") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Metabolic therapy: starving the tumour of a nutrient, not a curated reading list.
Shares Nutrient competition & metabolic immunosuppression, Radical oncology: what could change the war by 2035, Sarcomas (soft tissue, bone, GIST), Cytotoxic chemotherapy and the tag frontier.
Shares Radical oncology: what could change the war by 2035, Cytotoxic chemotherapy and the tag frontier.
Shares Radical oncology: what could change the war by 2035, Exercise & lifestyle oncology and the tag frontier.
Shares Nutrient competition & metabolic immunosuppression, Mesothelioma and the tag frontier.
Shares Radical oncology: what could change the war by 2035 and the tag frontier.
Shares Radical oncology: what could change the war by 2035 and the tag frontier.
Shares Radical oncology: what could change the war by 2035 and the tag frontier.
Shares Radical oncology: what could change the war by 2035 and the tag frontier.