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Magnetic nanoparticle hyperthermia injects iron-oxide nanoparticles into a tumour and heats them from outside with an alternating magnetic field.
NanoTherm received European approval for glioblastoma in 2010 and is used at a small number of German centres, usually with radiotherapy. A phase 2 adjuvant glioblastoma study is recruiting in Poland (NCT06271421); the US prostate focal-ablation study (NCT05010759) was terminated. Systemically delivered magnetic hyperthermia, as opposed to direct intratumoural injection, is still preclinical.
Superparamagnetic iron-oxide nanoparticles deposited in the tumour dissipate heat under an alternating magnetic field, reaching 40-45 °C and sensitising cells to radiation and chemotherapy.
Query for this technology: (TITLE:"Magnetic nanoparticle hyperthermia" OR ABSTRACT:"Magnetic nanoparticle hyperthermia") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Magnetic nanoparticle hyperthermia, not a curated reading list.
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