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Intratumoural gene electrotransfer injects a plasmid carrying the interleukin-12 gene into a tumour and pushes it into cells with electric pulses, so this T-cell-activating cytokine is made locally instead of at the toxic doses intravenous IL-12 needed. It produced responses with pembrolizumab in anti-PD-1-resistant melanoma, but the sponsor's programmes have stalled.
Tavokinogene telseplasmid with electroporation produced systemic responses when combined with pembrolizumab in anti-PD-1-refractory melanoma, and Moffitt ran a neoadjuvant study with nivolumab (NCT04526730, completed). The sponsor's TNBC study (NCT03567720) has unknown status, a head and neck study was terminated, and the company's programmes stalled. The concept, local cytokine expression without systemic toxicity, remains attractive and is being pursued with other constructs.
Short electric pulses transiently permeabilise cell membranes, letting plasmid DNA enter tumour cells that then secrete IL-12 locally, recruiting and activating T cells.
Query for this technology: (TITLE:"Intratumoural gene electrotransfer" OR ABSTRACT:"Intratumoural gene electrotransfer" OR TITLE:"IL-12 plasmid" OR ABSTRACT:"IL-12 plasmid") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Intratumoural gene electrotransfer (IL-12 plasmid), not a curated reading list.
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