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Treating one tumour so aggressively that the immune system learns to attack every other one, using the tumour itself as the vaccine.
Rather than manufacturing a vaccine, an injected adjuvant, virus, cytokine or ablative therapy turns a single lesion into an antigen source. Intratumoural TLR9 agonists with low-dose radiotherapy produced systemic responses in lymphoma, and oncolytic viruses, cryoablation, histotripsy and IL-12 electroporation all pursue the same idea. Systemic responses are real but modest and inconsistent, and the field lacks a way to predict who will respond.
Local immunogenic cell death plus an adjuvant recruits antigen-presenting cells at the tumour, priming T cells against the patient's own full antigen repertoire.
Query for this technology: (TITLE:"In situ vaccination" OR ABSTRACT:"In situ vaccination") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about In situ vaccination, not a curated reading list.
Shares Abscopal effect, Immunogenic cell death, Focused ultrasound & histotripsy, Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Abscopal effect, Radical oncology: what could change the war by 2035, SBRT / SABR (stereotactic radiotherapy) and the tags frontier, promising.
Shares Paths to cures: interception, eradication, control, Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Focused ultrasound & histotripsy, Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Paths to cures: interception, eradication, control, Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Paths to cures: interception, eradication, control, Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035, SBRT / SABR (stereotactic radiotherapy) and the tags frontier, promising.
Shares Paths to cures: interception, eradication, control, Radical oncology: what could change the war by 2035 and the tags frontier, promising.