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Adding a PARP or ATR inhibitor to a radioactive drug so the tumour cannot repair the damage the radiation causes.
Radioligand therapy kills by DNA damage, so blocking repair should amplify it. Early-phase studies combine 177Lu-PSMA with olaparib in prostate cancer and 177Lu-DOTATATE with PARP inhibitors in neuroendocrine tumours; the recurring question is whether marrow toxicity rises faster than tumour control. No phase 3 had read out by 2026.
Beta or alpha decay produces single- and double-strand breaks; PARP or ATR inhibition prevents repair, converting sublethal damage into cell death and lowering the activity required.
Query for this technology: (TITLE:"Radioligand plus DNA-repair inhibitor combinations" OR ABSTRACT:"Radioligand plus DNA-repair inhibitor combinations") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Radioligand plus DNA-repair inhibitor combinations, not a curated reading list.
Shares Radical oncology: what could change the war by 2035, Radiotherapy roadmap: X-rays → shaped beams → fewer fractions, particles and FLASH and the tags frontier, promising.
Shares Paths to cures: interception, eradication, control, Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035, Radiotherapy roadmap: X-rays → shaped beams → fewer fractions, particles and FLASH and the tags frontier, promising.
Shares Paths to cures: interception, eradication, control, Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Paths to cures: interception, eradication, control, Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Paths to cures: interception, eradication, control, Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Paths to cures: interception, eradication, control, Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Paths to cures: interception, eradication, control, Radical oncology: what could change the war by 2035 and the tags frontier, promising.