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Lattice radiotherapy deliberately treats a bulky tumour unevenly, placing peaks of tumour-destroying dose at spaced points inside it while the tissue between receives far less, relying on bystander and immune effects to extend the kill. It runs on standard linear accelerators, but evidence is mostly palliative and single-arm, and the mechanism is unsettled.
Spatially fractionated radiotherapy places vertices of ablative dose inside a bulky tumour while valleys receive far less, exploiting bystander and immune effects rather than uniform coverage. Studies active in 2026 include Memorial Sloan Kettering (NCT05837767, recruiting), a randomised comparison against conventional radiotherapy in China (NCT06980259, recruiting), and combinations with checkpoint blockade (NCT07428148, NYU; NCT07041788). Most published series are palliative and single-arm.
High-dose vertices spaced across the tumour create steep dose gradients; abscopal and bystander signalling plus vascular damage are proposed to extend the effect beyond the peaks.
Query for this technology: (TITLE:"Lattice and GRID radiotherapy" OR ABSTRACT:"Lattice and GRID radiotherapy") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Lattice and GRID radiotherapy, not a curated reading list.
Shares Radical oncology: what could change the war by 2035, Radiotherapy roadmap: X-rays → shaped beams → fewer fractions, particles and FLASH, SBRT / SABR (stereotactic radiotherapy), IMRT / IGRT (modern external beam) and the tags frontier, promising.
Shares Abscopal effect, Radical oncology: what could change the war by 2035, Immune checkpoint inhibitors and the tags frontier, promising.
Shares Abscopal effect, Radical oncology: what could change the war by 2035, SBRT / SABR (stereotactic radiotherapy) and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035, Immune checkpoint inhibitors and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035, Radiotherapy roadmap: X-rays → shaped beams → fewer fractions, particles and FLASH and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035, Immune checkpoint inhibitors and the tags frontier, promising.