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Destroying a tumour mechanically with sound, rather than heat, leaves the debris intact enough for the immune system to learn from it.
Histotripsy liquefies tissue by cavitation without heating, so tumour antigens and danger signals survive in a form that heat coagulation destroys. Preclinical models show abscopal responses and synergy with checkpoint blockade, and the approved liver device provides a clinical platform. Human immune data are early and no randomised combination trial has reported.
Microsecond ultrasound pulses generate a cavitation bubble cloud that mechanically fractionates tissue at the focus, releasing intact antigens and danger signals that prime an immune response.
Query for this technology: (TITLE:"Histotripsy as an immune primer" OR ABSTRACT:"Histotripsy as an immune primer") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Histotripsy as an immune primer, not a curated reading list.
Shares Abscopal effect, Immunogenic cell death, Focused ultrasound & histotripsy, Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Abscopal effect, Radical oncology: what could change the war by 2035, Immune checkpoint inhibitors and the tags frontier, promising.
Shares Focused ultrasound & histotripsy, Radical oncology: what could change the war by 2035, Devices and physical therapies roadmap: heat and light → electric fields and focused sound → drug-releasing implants and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035, Devices and physical therapies roadmap: heat and light → electric fields and focused sound → drug-releasing implants and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035, Immune checkpoint inhibitors and the tags frontier, promising.
Shares Focused ultrasound & histotripsy, Radical oncology: what could change the war by 2035, Devices and physical therapies roadmap: heat and light → electric fields and focused sound → drug-releasing implants, Thermal ablation (RFA, microwave, cryo) and the tag frontier.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035, Immune checkpoint inhibitors and the tags frontier, promising.