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Immunogenic cell death is a way of dying that alerts the immune system, unlike quiet apoptosis.
Immunogenic cell death is a way for a cell to die that alerts the immune system, in contrast to quiet apoptosis. It is marked by calreticulin exposure, release of ATP and HMGB1, and type I interferon, and it can be induced by anthracyclines, oxaliplatin, radiation, some ADC payloads, oncolytic viruses and photoimmunotherapy. This is the basis for synergy between chemotherapy and immunotherapy and between ADCs and immunotherapy. The term is linked to the Antibody-drug conjugate (ADC), Oncolytic viruses and Photoimmunotherapy & photodynamic therapy technologies and is cited by In situ vaccination, Histotripsy as an immune primer, Electrochemotherapy, the cGAS-STING pathway, the terms Apoptosis and Necrosis, Laurence Zitvogel and the bottleneck on cold tumours.
Showing the technology this term belongs to: Antibody-drug conjugate (ADC).
Shares Histotripsy as an immune primer, Mechanically pulverise one tumour with ultrasound to wake the immune system, Pick the radiation dose that switches the immune alarm on, not off, Turn one tumour into a vaccine to treat all the others.
Shares Turn one tumour into a vaccine to treat all the others, In situ vaccination, cGAS-STING innate sensing, The cancer-immunity cycle.
Shares Histotripsy as an immune primer, Mechanically pulverise one tumour with ultrasound to wake the immune system.
Shares Photoimmunotherapy & photodynamic therapy, Photoimmunotherapy as an in situ vaccine with PD-1 blockade.
Shares Laurence Zitvogel, Cold tumours and the immunosuppressive microenvironment.
Shares Pick the radiation dose that switches the immune alarm on, not off, cGAS-STING innate sensing.
Shares Histotripsy as an immune primer, Mechanically pulverise one tumour with ultrasound to wake the immune system, In situ vaccination.
Shares Mechanically pulverise one tumour with ultrasound to wake the immune system, Pick the radiation dose that switches the immune alarm on, not off, Turn one tumour into a vaccine to treat all the others, Cold tumours and the immunosuppressive microenvironment.