{"entity":{"id":"immunogenic-cell-death","kind":"term","name":"Immunogenic cell death","aka":[],"tldr":"Immunogenic cell death is a way of dying that alerts the immune system, unlike quiet apoptosis.","summary":"Immunogenic cell death is a way for a cell to die that alerts the immune system, in contrast to quiet apoptosis. It is marked by calreticulin exposure, release of ATP and HMGB1, and type I interferon, and it can be induced by anthracyclines, oxaliplatin, radiation, some ADC payloads, oncolytic viruses and photoimmunotherapy. This is the basis for synergy between chemotherapy and immunotherapy and between ADCs and immunotherapy. The term is linked to the Antibody-drug conjugate (ADC), Oncolytic viruses and Photoimmunotherapy & photodynamic therapy technologies and is cited by In situ vaccination, Histotripsy as an immune primer, Electrochemotherapy, the cGAS-STING pathway, the terms Apoptosis and Necrosis, Laurence Zitvogel and the bottleneck on cold tumours.","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/Immunogenic_cell_death","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Immunogenic_cell_death"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":["adc","oncolytic-virus","photoimmunotherapy"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"category":"Immunology"},"route":"/terms/immunogenic-cell-death/","neighbours":{"technology":[{"id":"adc","kind":"technology","name":"Antibody-drug conjugate (ADC)","route":"/technologies/adc/"},{"id":"electrochemotherapy","kind":"technology","name":"Electrochemotherapy","route":"/technologies/electrochemotherapy/"},{"id":"histotripsy-immune-priming","kind":"technology","name":"Histotripsy as an immune primer","route":"/technologies/histotripsy-immune-priming/"},{"id":"in-situ-vaccination","kind":"technology","name":"In situ vaccination","route":"/technologies/in-situ-vaccination/"},{"id":"oncolytic-virus","kind":"technology","name":"Oncolytic viruses","route":"/technologies/oncolytic-virus/"},{"id":"photoimmunotherapy","kind":"technology","name":"Photoimmunotherapy & photodynamic therapy","route":"/technologies/photoimmunotherapy/"}],"idea":[{"id":"idea-bio2-histotripsy-immune-priming","kind":"idea","name":"Mechanically pulverise one tumour with ultrasound to wake the immune system","route":"/ideas/idea-bio2-histotripsy-immune-priming/"},{"id":"idea-photoimmunotherapy-plus-pd1","kind":"idea","name":"Photoimmunotherapy as an in situ vaccine with PD-1 blockade","route":"/ideas/idea-photoimmunotherapy-plus-pd1/"},{"id":"idea-bio2-radiotherapy-sting-fractionation","kind":"idea","name":"Pick the radiation dose that switches the immune alarm on, not off","route":"/ideas/idea-bio2-radiotherapy-sting-fractionation/"},{"id":"idea-bio2-in-situ-vaccination-solid","kind":"idea","name":"Turn one tumour into a vaccine to treat all the others","route":"/ideas/idea-bio2-in-situ-vaccination-solid/"}],"pathway":[{"id":"cgas-sting","kind":"pathway","name":"cGAS-STING innate sensing","route":"/pathways/cgas-sting/"},{"id":"extrinsic-apoptosis-death-receptors","kind":"pathway","name":"Extrinsic apoptosis (death receptors)","route":"/pathways/extrinsic-apoptosis-death-receptors/"},{"id":"cancer-immunity-cycle","kind":"pathway","name":"The cancer-immunity cycle","route":"/pathways/cancer-immunity-cycle/"}],"person":[{"id":"laurence-zitvogel","kind":"person","name":"Laurence Zitvogel","route":"/people/laurence-zitvogel/"}],"bottleneck":[{"id":"b-tme-immunosuppression","kind":"bottleneck","name":"Cold tumours and the immunosuppressive microenvironment","route":"/bottlenecks/b-tme-immunosuppression/"}],"term":[{"id":"apoptosis","kind":"term","name":"Apoptosis","route":"/terms/apoptosis/"},{"id":"necrosis","kind":"term","name":"Necrosis","route":"/terms/necrosis/"}]}}