Loading
When irradiating one tumour causes untreated tumours elsewhere to shrink, via the immune system.
The abscopal effect is the phenomenon in which irradiating one tumour causes untreated tumours elsewhere in the body to shrink, mediated by the immune system. It is rare with radiotherapy alone and more frequent when combined with Immune checkpoint inhibitors, and the mechanism runs through cGAS-STING innate sensing, antigen release and T-cell priming. It is the rationale for trials of SBRT / SABR (stereotactic radiotherapy) plus immunotherapy, which have given mixed results, PEMBRO-RT being positive and others negative. The term is linked to the pairing Radiotherapy + immunotherapy, to Lattice and GRID radiotherapy, In situ vaccination and Histotripsy as an immune primer, and to an idea on turning one tumour into a vaccine for all the others.
Showing the technology this term belongs to: SBRT / SABR (stereotactic radiotherapy).
Shares Histotripsy as an immune primer, Mechanically pulverise one tumour with ultrasound to wake the immune system, Pick the radiation dose that switches the immune alarm on, not off, Turn one tumour into a vaccine to treat all the others.
Shares Histotripsy as an immune primer, Mechanically pulverise one tumour with ultrasound to wake the immune system.
Shares Turn one tumour into a vaccine to treat all the others, In situ vaccination, cGAS-STING innate sensing, Cold tumours and the immunosuppressive microenvironment.
Shares Histotripsy as an immune primer, Mechanically pulverise one tumour with ultrasound to wake the immune system, In situ vaccination.
Shares Mechanically pulverise one tumour with ultrasound to wake the immune system, Pick the radiation dose that switches the immune alarm on, not off, Turn one tumour into a vaccine to treat all the others, Cold tumours and the immunosuppressive microenvironment.
Shares Cancer Center Clínica Universidad de Navarra / CIMA, Immune checkpoint inhibitors.
Shares Radiotherapy, SBRT / SABR (stereotactic radiotherapy), Immune checkpoint inhibitors.
Shares cGAS-STING innate sensing, Cold tumours and the immunosuppressive microenvironment.