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Focused ultrasound can break a tumour apart without heat or cuts, leaving debris the immune system can learn from. Doing that to one tumour may help treat the rest.
Histotripsy destroys tissue mechanically through cavitation, is now approved for liver tumour destruction, and leaves antigenic debris and intact immune signals rather than the coagulated protein produced by thermal ablation. Mouse studies show abscopal effects and increased T-cell priming, and combination with checkpoint blockade is being explored in early trials.
Shares HistoSonics, Abscopal effect, Immunogenic cell death, Focused ultrasound & histotripsy.
Shares Abscopal effect, Immunogenic cell death, Estimation of the Percentage of US Patients With Cancer Who Are Eligible for and Respond to Checkpoint Inhibitor Immunotherapy Drugs, Cold tumours and the immunosuppressive microenvironment.
Shares HistoSonics, Irreversible electroporation (NanoKnife), Focused ultrasound & histotripsy, Thermal ablation (RFA, microwave, cryo).
Shares Abscopal effect, Immunogenic cell death, Estimation of the Percentage of US Patients With Cancer Who Are Eligible for and Respond to Checkpoint Inhibitor Immunotherapy Drugs, Cold tumours and the immunosuppressive microenvironment.
Shares Abscopal effect, Immunogenic cell death, Focused ultrasound & histotripsy, Thermal ablation (RFA, microwave, cryo).
Shares Estimation of the Percentage of US Patients With Cancer Who Are Eligible for and Respond to Checkpoint Inhibitor Immunotherapy Drugs, Cold tumours and the immunosuppressive microenvironment, Colorectal cancer, Immune checkpoint inhibitors.
Shares Irreversible electroporation (NanoKnife), Focused ultrasound & histotripsy, Thermal ablation (RFA, microwave, cryo), Hepatocellular carcinoma.
Shares Estimation of the Percentage of US Patients With Cancer Who Are Eligible for and Respond to Checkpoint Inhibitor Immunotherapy Drugs, Cold tumours and the immunosuppressive microenvironment, Colorectal cancer, Immune checkpoint inhibitors.