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Irreversible electroporation uses short high-voltage pulses that punch permanent holes in tumour cells while sparing nearby vessels and ducts.
Irreversible electroporation delivers microsecond high-voltage pulses between needle electrodes, permanently disrupting cell membranes while leaving collagenous structures such as vessels and ducts intact. This non-thermal mechanism is why it is used in locally advanced pancreatic cancer wrapped around vessels, where heat-based ablation would be unsafe, and in focal prostate therapy (FDA 2024 for prostate). The procedure requires general anaesthesia with muscle paralysis and cardiac synchronisation, because the pulses can trigger contractions and arrhythmia. Randomised data remain limited, so its survival benefit in pancreatic cancer is not yet established. The simple version is that electrical pulses punch permanent holes in tumour cells while sparing the pipes running through them.
Microsecond electrical pulses between needle electrodes disrupt membranes irreversibly.
Query for this technology: (TITLE:"irreversible electroporation" OR ABSTRACT:"irreversible electroporation" OR TITLE:"NanoKnife" OR ABSTRACT:"NanoKnife"). Results are unfiltered search hits about Irreversible electroporation (NanoKnife), not a curated reading list.
Shares Mechanically pulverise one tumour with ultrasound to wake the immune system, Device-agnostic public trials of ablation technologies against surgery, Devices and physical therapies roadmap: heat and light → electric fields and focused sound → drug-releasing implants, Surgery roadmap: radical operations → less surgery → no surgery when a drug has done the work.
Shares Mechanically pulverise one tumour with ultrasound to wake the immune system, Device-agnostic public trials of ablation technologies against surgery, Microwave and radiofrequency ablation systems, Devices and physical therapies roadmap: heat and light → electric fields and focused sound → drug-releasing implants.
Shares Cryoablation systems, Devices and physical therapies roadmap: heat and light → electric fields and focused sound → drug-releasing implants, Surgery roadmap: radical operations → less surgery → no surgery when a drug has done the work.
Shares Electrochemotherapy, Electrochemotherapy devices (Cliniporator).
Shares Cryoablation systems, Microwave and radiofrequency ablation systems, Devices and physical therapies roadmap: heat and light → electric fields and focused sound → drug-releasing implants, Locally advanced unresectable pancreatic ductal adenocarcinoma.
Shares Cryoablation systems, Microwave and radiofrequency ablation systems, Prostate cancer.
Shares AngioDynamics, Mechanically pulverise one tumour with ultrasound to wake the immune system, Device-agnostic public trials of ablation technologies against surgery, Cryoablation systems.
Shares CROSSFIRE, Locally advanced unresectable pancreatic ductal adenocarcinoma, Pancreatic ductal adenocarcinoma.