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Giving the same drug at a different time of day, because the body clock changes how much damage it does and how well the immune system responds.
Retrospective series repeatedly report better outcomes when checkpoint inhibitors are infused earlier in the day, and chronomodulated chemotherapy has a long European history in colorectal cancer with mixed randomised results. The signal is confounded: patients infused late are often sicker or attend different clinics. Prospective randomised trials of infusion timing are small and ongoing, and nothing has changed practice.
Circadian variation in drug metabolism, DNA repair and immune-cell trafficking makes both toxicity and efficacy depend on time of day.
Query for this technology: (TITLE:"Chronotherapy: timing treatment to the body clock" OR ABSTRACT:"Chronotherapy: timing treatment to the body clock") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Chronotherapy: timing treatment to the body clock, not a curated reading list.
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