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Cells or drugs that fire only when two conditions are true at once, so healthy tissue expressing just one of them is spared.
SynNotch and similar circuits require antigen A to license killing of antigen B; NOT gates use an inhibitory receptor against an antigen present only on normal tissue. Tmod NOT-gated CAR-T exploiting HLA loss of heterozygosity is in early-phase trials, and AND-gated constructs are in phase 1 for solid tumours. Logic gating is the leading answer to on-target off-tumour toxicity, but circuit complexity reduces potency and manufacturability.
A synthetic receptor circuit integrates two antigen inputs; killing proceeds only if the required combination is present, and is blocked if a protective antigen is detected.
Query for this technology: (TITLE:"Logic-gated therapeutics" OR ABSTRACT:"Logic-gated therapeutics" OR TITLE:"AND, NOT gates" OR ABSTRACT:"AND, NOT gates") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Logic-gated therapeutics (AND, NOT gates), not a curated reading list.
Shares In vivo CAR-T, Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Paths to cures: interception, eradication, control, Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares In vivo CAR-T, Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Paths to cures: interception, eradication, control, Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Paths to cures: interception, eradication, control, Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Paths to cures: interception, eradication, control, Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Paths to cures: interception, eradication, control, Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Paths to cures: interception, eradication, control, Radical oncology: what could change the war by 2035 and the tags frontier, promising.