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Arsenal Biosciences
Programmable CAR-T company using logic gates so cells fire only when two tumour proteins are present; AB-2100 (PSMA + CA9) is in phase 1/2 for kidney cancer.
Overview
Arsenal Biosciences, based in South San Francisco, is a programmable CAR-T company that uses logic gates so its cells fire only when two tumour proteins are present, and its AB-2100 is in phase 1/2 for kidney cancer. AB-2100 combines a synthetic AND gate requiring both PSMA and CA9, shRNA armouring against suppression in the tumour microenvironment and a synthetic pathway activator, and is being tested in clear-cell renal cell carcinoma after immunotherapy and VEGF therapy in trial NCT06245915; AB-1015 targets ovarian cancer, and the company raised 325 million dollars with Regeneron and Bristol Myers Squibb participating. OnCo links it to renal and ovarian cancer, to armoured and logic-gated CARs and logic-gated therapeutics, and to PSMA as a target. Whether logic gating solves the on-target, off-tumour problem that has stalled solid-tumour CAR-T is the question its trial will test.
Notes
top- The Parker Institute for Cancer Immunotherapy's own news pages describe ArsenalBio as a company it launched in 2019, with a founders' interview on the institute's site.
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