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Loading the tiny vesicles cells naturally use to talk to each other with a cancer drug, so the body treats the carrier as its own.
Exosomes are natural lipid vesicles that cross biological barriers and are poorly cleared by the immune system. The best-known oncology example is iExosomes, mesenchymal-cell exosomes loaded with siRNA against KRAS G12D, in a phase 1 in pancreatic cancer at MD Anderson (NCT03608631). Manufacturing consistency, loading efficiency and potency per particle are the barriers; no exosome therapeutic has been approved.
Donor cells are engineered or exosomes are loaded ex vivo with siRNA, protein or small molecules; surface proteins such as CD47 reduce clearance and can be modified for targeting.
Query for this technology: (TITLE:"Engineered exosomes as drug carriers" OR ABSTRACT:"Engineered exosomes as drug carriers") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Engineered exosomes as drug carriers, not a curated reading list.
Shares In vivo CAR-T, Radical oncology: what could change the war by 2035, Personalised neoantigen (mRNA) vaccines and the tags frontier, promising.
Shares In vivo CAR-T, Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035, Personalised neoantigen (mRNA) vaccines and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035, Pancreatic ductal adenocarcinoma and the tags frontier, promising.
Shares Radical oncology: what could change the war by 2035 and the tags frontier, promising.