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A drug that does nothing until ultrasound hits it, then kills the cells that took it up. Being tested in brain tumours because sound reaches where light cannot.
5-ALA accumulates as protoporphyrin IX in glioma cells; focused or diffuse ultrasound then generates reactive oxygen species locally. Alpheus Medical is running a phase 2 in newly diagnosed glioblastoma with adjuvant temozolomide (NCT07225621, recruiting) after a completed phase 1 (NCT05362409); Insightec's ExAblate platform completed a phase 2 (NCT04845919) and investigator studies are recruiting in recurrent glioblastoma (NCT06039709). No randomised survival data exist yet.
A sonosensitiser concentrates in tumour cells; ultrasound induces cavitation and reactive oxygen species that kill sensitised cells while sparing normal brain.
Query for this technology: (TITLE:"Sonodynamic therapy" OR ABSTRACT:"Sonodynamic therapy") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Sonodynamic therapy, not a curated reading list.
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Shares Radical oncology: what could change the war by 2035 and the tags frontier, promising.