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Sound waves plus microbubbles briefly open the brain's protective barrier so chemotherapy or antibodies can get to the tumour.
MR-guided (Insightec Exablate) or implantable (Carthera SonoCloud-9) ultrasound with intravenous microbubbles transiently and reversibly opens the BBB. Phase 1/2 trials show 4-6x higher brain concentrations of carboplatin, temozolomide, and albumin-bound paclitaxel, and enable liquid biopsy of glioma DNA released into blood. Efficacy trials (SonoCloud-9 with carboplatin, phase 3 SONOBIRD) are underway.
Acoustic cavitation of circulating microbubbles mechanically loosens endothelial tight junctions for several hours.
Query for this technology: (TITLE:"Focused-ultrasound blood-brain barrier opening" OR ABSTRACT:"Focused-ultrasound blood-brain barrier opening") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Focused-ultrasound blood-brain barrier opening, not a curated reading list.
Shares Carthera, A skull ultrasound implant that opens the barrier at every cycle, Transcranial focused ultrasound systems (Exablate Neuro, SonoCloud), Glioma & glioblastoma.
Shares Open the barrier so engineered immune cells can enter the brain, Blood-brain barrier (BBB), The blood-brain barrier & brain metastasis, Diffuse midline glioma, H3 K27-altered (including DIPG).
Shares Blood-brain barrier (BBB), The blood-brain barrier & brain metastasis, Devices and physical therapies roadmap: heat and light → electric fields and focused sound → drug-releasing implants, The brain: barrier and sanctuary.
Shares Insightec, Diffuse midline glioma, H3 K27-altered (including DIPG), Brain and spinal cord tumours (all types), Glioma & glioblastoma.
Shares Insightec, Diffuse midline glioma, H3 K27-altered (including DIPG), Brain and spinal cord tumours (all types), Glioma & glioblastoma.
Shares Insightec, Focused ultrasound & histotripsy, The brain: barrier and sanctuary, Glioma & glioblastoma.
Shares Focused ultrasound & histotripsy, Devices and physical therapies roadmap: heat and light → electric fields and focused sound → drug-releasing implants, MRI, Glioma & glioblastoma.
Shares UVA Comprehensive Cancer Center, Focused ultrasound & histotripsy, Devices and physical therapies roadmap: heat and light → electric fields and focused sound → drug-releasing implants.