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The tight seal around brain blood vessels that keeps most drugs out, one of the two main reasons brain cancer is so hard to treat.
Endothelial tight junctions, efflux transporters (P-gp, BCRP), and pericytes exclude most antibodies and all but small, lipophilic small molecules. Glioblastoma disrupts the barrier heterogeneously (contrast enhancement) but infiltrating cells sit behind intact barrier. Strategies: lipophilic/small brain-penetrant drugs (temozolomide, lomustine, dordaviprone, vorasidenib), locoregional delivery (CAR-T, convection-enhanced), focused-ultrasound opening, LITT, and intra-arterial delivery.
Showing the technology this term belongs to: Focused-ultrasound blood-brain barrier opening.
Shares CheckMate 143, CheckMate 498, CheckMate 548, CAR-T for glioma (IL13Rα2, GD2, EGFRvIII, multi-target).
Shares CheckMate 498, CheckMate 548, The blood-brain barrier & brain metastasis, Astrocytoma, IDH-mutant (grades 2 to 4).
Shares Use the brain's own transport door to carry antibody drugs across, Organ tropism: seed and soil, The blood-brain barrier & brain metastasis, Brain metastases (secondary brain tumours).
Shares Dordaviprone, CAR-T for glioma (IL13Rα2, GD2, EGFRvIII, multi-target), Diffuse midline glioma, H3 K27-altered (including DIPG), The brain: barrier and sanctuary.
Shares CAR-T for glioma (IL13Rα2, GD2, EGFRvIII, multi-target), Focused-ultrasound blood-brain barrier opening, The brain: barrier and sanctuary, Glioma & glioblastoma.
Shares Dordaviprone, Primary CNS lymphoma, Medulloblastoma, Glioma & glioblastoma.
Shares Ultrasound-assisted blood test instead of a brain biopsy, Focused-ultrasound blood-brain barrier opening, The brain: barrier and sanctuary, Glioma & glioblastoma.
Shares Robot-placed catheters and live imaging for drug infusion into brain tumours, Lomustine (CCNU), Glioma & glioblastoma.