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Brain tumours have targets that ADCs could hit, but antibodies cannot cross the barrier. Open the barrier with ultrasound first.
Depatuxizumab mafodotin (EGFR ADC) failed in INTELLANCE-1 partly through poor CNS penetration. Focused ultrasound raises antibody delivery several-fold in humans (Insightec, Carthera trials). Combining BBB opening with EGFR/EGFRvIII or B7-H3 ADCs, or with 177Lu/225Ac radioconjugates, is untested clinically.
One idea page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One of the most cited reviews Europe PMC returns for B7-H3 in Glioma & glioblastoma, so it is a natural first reading for anyone weighing the idea it is linked from. The record was linked automatically by title and abstract; read the abstract above and the paper itself before relying on any figure.
One of the most cited reviews Europe PMC returns for EGFR in Glioma & glioblastoma, so it is a natural first reading for anyone weighing the idea it is linked from. The record was linked automatically by title and abstract; read the abstract above and the paper itself before relying on any figure.
One of the most cited reviews Europe PMC returns for EGFR in Glioma & glioblastoma, so it is a natural first reading for anyone weighing the idea it is linked from. The record was linked automatically by title and abstract; read the abstract above and the paper itself before relying on any figure.
Shares Oncogenic EGFR signaling networks in glioma, Emerging functions of the EGFR in cancer, EGFR, Glioma & glioblastoma.
Shares Focused-ultrasound blood-brain barrier opening, Blood-brain barrier (BBB), The brain: barrier and sanctuary, Glioma & glioblastoma.
Shares Focused-ultrasound blood-brain barrier opening, B7-H3, The brain: barrier and sanctuary, Glioma & glioblastoma.
Shares Blood-brain barrier (BBB), The brain: barrier and sanctuary, Glioma & glioblastoma.
Shares Radio-antibody & radio-ADC, B7-H3, Antibody-drug conjugate (ADC).
Shares Blood-brain barrier (BBB), The brain: barrier and sanctuary, Glioma & glioblastoma.
Shares Blood-brain barrier (BBB), The brain: barrier and sanctuary, Glioma & glioblastoma.
Shares Blood-brain barrier (BBB), The brain: barrier and sanctuary, Glioma & glioblastoma.