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A small ultrasound device implanted in the skull can be switched on at each chemotherapy visit to briefly open the brain barrier, letting drugs in every cycle.
Implantable ultrasound emitters have been used in recurrent glioblastoma trials with carboplatin and with albumin-bound paclitaxel, showing repeated safe barrier opening and increased brain drug concentrations. The remaining questions are whether the added exposure translates into survival, and which drug benefits most from repeated opening.
One of the most cited trial reports Europe PMC returns for Carboplatin in Glioma & glioblastoma, so it is a natural first reading for anyone weighing the idea it is linked from. The record was linked automatically by title and abstract; read the abstract above and the paper itself before relying on any figure.
One of the most cited trial reports Europe PMC returns for Carboplatin in Glioma & glioblastoma, so it is a natural first reading for anyone weighing the idea it is linked from. The record was linked automatically by title and abstract; read the abstract above and the paper itself before relying on any figure.
One of the most cited trial reports Europe PMC returns for Carboplatin in Glioma & glioblastoma, so it is a natural first reading for anyone weighing the idea it is linked from. The record was linked automatically by title and abstract; read the abstract above and the paper itself before relying on any figure.
Shares Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM, Focused-ultrasound blood-brain barrier opening, Glioma & glioblastoma.
Shares Focused-ultrasound blood-brain barrier opening, Blood-brain barrier (BBB), The brain: barrier and sanctuary, Glioma & glioblastoma.
Shares Blood-brain barrier (BBB), The brain: barrier and sanctuary, Glioma & glioblastoma, Cytotoxic chemotherapy.
Shares A randomized, double-blind, placebo-controlled, phase 2 study of RMP-7 in combination with carboplatin administered intravenously for the treatment of recurrent malignant glioma, Randomized phase 2 study of carboplatin and bevacizumab in recurrent glioblastoma, Glioma & glioblastoma.
Shares Blood-brain barrier (BBB), The brain: barrier and sanctuary, Temozolomide, Glioma & glioblastoma.
Shares Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM, Focused-ultrasound blood-brain barrier opening, Temozolomide, Glioma & glioblastoma.
Shares Temozolomide, Glioma & glioblastoma, Cytotoxic chemotherapy.
Shares Temozolomide, Glioma & glioblastoma, Cytotoxic chemotherapy.