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Trials
A Study of NanO2™ Combined With Radiation and Temozolomide in Patients With Newly Diagnosed GBM

trialsTrialActive

A Study of NanO2™ Combined With Radiation and Temozolomide in Patients With Newly Diagnosed GBM

A phase 2 trial of NanO2TM in glioma & glioblastoma, run by NuvOx LLC, active and no longer recruiting.

Also called: RESTORE

Overview Connected3

Overview

A Study of NanO2™ Combined With Radiation and Temozolomide in Patients With Newly Diagnosed GBM is a phase 2 interventional study registered as NCT03862430 by NuvOx LLC, with 87 participants enrolled, started 2023-03-31 and due to reach its primary completion in 2027-06-30. Interventions recorded: NanO2TM and Placebo Saline Infusion.

Setting

A Phase II Double-blind, RandomizEd, Prospective, Placebo Controlled STudy of NanO2TM Combined With Radiation and Temozolomide in Patients With Newly-diagnosed Glioblastoma multiformE: RESTORE

Phase

Phase 2

Sponsor

NuvOx LLC

Registry

Started

2023-03-31

Enrolled

87 enrolled

Connected

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cancers

Glioma & glioblastoma

technologies

Cytotoxic chemotherapy

drugs

ApprovedOral alkylating chemotherapy

Temozolomide · Temodar

Evidence strength30/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 2+15
87 enrolled+10
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT03862430

Data

JSON ·

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Cancers

Glioma & glioblastoma

Technologies

Cytotoxic chemotherapy

Products

Temozolomide

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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