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Brain tumours release little DNA into blood because of the blood-brain barrier. Sonobiopsy briefly opens the barrier with focused ultrasound and microbubbles, raising circulating tumour DNA severalfold so a blood sample can replace repeat surgical biopsy for diagnosis and resistance monitoring in glioma and brain metastases.
Focused ultrasound with microbubbles transiently opens the blood-brain barrier, and first-in-human sonobiopsy studies report severalfold increases in circulating tumour DNA and brain-derived proteins after sonication, without lasting damage. This could replace repeat surgical biopsy for molecular diagnosis, resistance monitoring and response assessment in glioma and brain metastases.
Shares Insightec, Focused-ultrasound blood-brain barrier opening, The brain: barrier and sanctuary, Glioma & glioblastoma.
Shares The brain: barrier and sanctuary, Circulating tumour DNA (ctDNA), MRD / molecular residual disease testing, Liquid biopsy (ctDNA).
Shares Blood-brain barrier (BBB), The brain: barrier and sanctuary, Glioma & glioblastoma.
Shares Insightec, The brain: barrier and sanctuary, Glioma & glioblastoma.
Shares Tumour heterogeneity and clonal evolution, Circulating tumour DNA (ctDNA), MRD / molecular residual disease testing, Liquid biopsy (ctDNA).
Shares Insightec, Focused-ultrasound blood-brain barrier opening, Glioma & glioblastoma.
Shares Tumour heterogeneity and clonal evolution, Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA).
Shares Circulating tumour DNA (ctDNA), MRD / molecular residual disease testing, Liquid biopsy (ctDNA).