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Insightec
MR-guided focused ultrasound company, with oncology use in blood-brain-barrier opening for brain tumours.
Overview
Insightec, based in Haifa, is the MR-guided focused ultrasound company whose oncology relevance lies in opening the blood-brain barrier so that drugs can reach brain tumours. Its Exablate Neuro system is established in essential tremor, Exablate Prostate treats prostate tissue, and its blood-brain barrier opening trials aim at drug delivery in glioblastoma. OnCo links it to glioma and glioblastoma, to focused ultrasound and histotripsy, focused-ultrasound blood-brain barrier opening and sonodynamic therapy, to Sunnybrook and the UVA cancer centre, and to ideas such as a standard platform for getting drugs into the brain and an ultrasound-assisted blood test instead of a brain biopsy. The brain as a barrier and sanctuary is the bottleneck it exists to breach. Whether transient barrier opening improves outcomes, not just drug levels, is the open question.
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Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG)Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPGBlood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets