{"entity":{"id":"insightec","kind":"company","name":"Insightec","aka":[],"tldr":"MR-guided focused ultrasound company, with oncology use in blood-brain-barrier opening for brain tumours.","summary":"Insightec, based in Haifa, is the MR-guided focused ultrasound company whose oncology relevance lies in opening the blood-brain barrier so that drugs can reach brain tumours. Its Exablate Neuro system is established in essential tremor, Exablate Prostate treats prostate tissue, and its blood-brain barrier opening trials aim at drug delivery in glioblastoma. OnCo links it to glioma and glioblastoma, to focused ultrasound and histotripsy, focused-ultrasound blood-brain barrier opening and sonodynamic therapy, to Sunnybrook and the UVA cancer centre, and to ideas such as a standard platform for getting drugs into the brain and an ultrasound-assisted blood test instead of a brain biopsy. The brain as a barrier and sanctuary is the bottleneck it exists to breach. Whether transient barrier opening improves outcomes, not just drug levels, is the open question.","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/Insightec","links":[{"label":"Official website","url":"https://www.insightec.com"}],"tags":[],"related":[],"cancers":[],"sections":["surgery","devices"],"technologies":["hifu-histotripsy"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct05317858","nct05615623","nct05630209"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"hq":"Haifa","country":"IL","companyType":"devices","website":"https://www.insightec.com","investors":[],"funding":[]},"route":"/companies/insightec/","neighbours":{"section":[{"id":"devices","kind":"section","name":"Devices & Physical Therapies","route":"/fronts/devices/"},{"id":"surgery","kind":"section","name":"Surgery & Interventional","route":"/fronts/surgery/"}],"technology":[{"id":"hifu-histotripsy","kind":"technology","name":"Focused ultrasound & histotripsy","route":"/technologies/hifu-histotripsy/"},{"id":"bbb-focused-ultrasound","kind":"technology","name":"Focused-ultrasound blood-brain barrier opening","route":"/technologies/bbb-focused-ultrasound/"},{"id":"sonodynamic-therapy","kind":"technology","name":"Sonodynamic therapy","route":"/technologies/sonodynamic-therapy/"},{"id":"transcranial-focused-ultrasound-systems","kind":"technology","name":"Transcranial focused ultrasound systems (Exablate Neuro, SonoCloud)","route":"/technologies/transcranial-focused-ultrasound-systems/"}],"trial":[{"id":"nct05630209","kind":"trial","name":"Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG)","route":"/trials/nct05630209/"},{"id":"nct05615623","kind":"trial","name":"Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric DIPG","route":"/trials/nct05615623/"},{"id":"nct05317858","kind":"trial","name":"Blood-brain Barrier (BBB) Opening Using Exablate Focused Ultrasound With Standard of Care Treatment of NSCLC Brain Mets","route":"/trials/nct05317858/"}],"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}],"bottleneck":[{"id":"b-brain-delivery","kind":"bottleneck","name":"The brain: barrier and sanctuary","route":"/bottlenecks/b-brain-delivery/"}],"idea":[{"id":"idea-moon-brain-delivery-platform","kind":"idea","name":"A standard platform to get drugs into the brain: focused ultrasound plus shuttle-engineered therapeutics","route":"/ideas/idea-moon-brain-delivery-platform/"},{"id":"idea-fund-ablation-versus-surgery-trials","kind":"idea","name":"Device-agnostic public trials of ablation technologies against surgery","route":"/ideas/idea-fund-ablation-versus-surgery-trials/"},{"id":"idea-bio2-fus-for-cell-entry","kind":"idea","name":"Open the barrier so engineered immune cells can enter the brain","route":"/ideas/idea-bio2-fus-for-cell-entry/"},{"id":"idea-bio2-sonobiopsy","kind":"idea","name":"Ultrasound-assisted blood test instead of a brain biopsy","route":"/ideas/idea-bio2-sonobiopsy/"}],"institution":[{"id":"sunnybrook-odette","kind":"institution","name":"Sunnybrook Odette Cancer Centre","route":"/institutions/sunnybrook-odette/"},{"id":"uva-cancer-center","kind":"institution","name":"UVA Comprehensive Cancer Center","route":"/institutions/uva-cancer-center/"}],"roadmap":[{"id":"devices-roadmap","kind":"roadmap","name":"Devices and physical therapies roadmap: heat and light → electric fields and focused sound → drug-releasing implants","route":"/roadmaps/devices-roadmap/"}]}}