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Most cancer drugs cannot cross into the brain. Combine ultrasound that briefly opens the barrier with drugs engineered to be carried across, and make this a standard platform for every brain tumour and brain metastasis.
The blood-brain barrier excludes most antibodies and many small molecules, limiting therapy for glioblastoma and brain metastases from lung, breast and melanoma. Focused ultrasound with microbubbles transiently opens the barrier and has delivered chemotherapy and antibodies in early trials; receptor-mediated shuttles (transferrin receptor) carry biologics across in neurology. The proposal is a platform programme: standardised ultrasound protocols and devices, a library of shuttle-enabled versions of active cancer drugs (antibody-drug conjugates, checkpoint inhibitors, bispecifics), pharmacokinetic validation in humans, and a trial network to test them in brain tumours and metastases.
Shares The brain: barrier and sanctuary, HER2-positive breast cancer, Melanoma, Non-small-cell lung cancer.
Shares Insightec, The brain: barrier and sanctuary, Glioma & glioblastoma.
Shares Insightec, Focused ultrasound & histotripsy, Glioma & glioblastoma.
Shares Insightec, Focused ultrasound & histotripsy, Melanoma.
Shares Insightec, Glioma & glioblastoma.
Shares Insightec, Glioma & glioblastoma.
Shares The brain: barrier and sanctuary, HER2-positive breast cancer, Melanoma, Non-small-cell lung cancer.
Shares Insightec, The brain: barrier and sanctuary, Glioma & glioblastoma.