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Drugs that reach brain tissue may still fail to reach the fluid where cancer spreads along the linings. A lab model of that second barrier would let us screen for drugs that cross it.
Leptomeningeal disease is governed by the blood-cerebrospinal fluid barrier at the choroid plexus, which differs from the blood-brain barrier in transporters and tight junction composition. Stem-cell-derived choroid plexus organoids that produce cerebrospinal fluid-like secretion have been reported, giving a human in vitro system for screening cerebrospinal fluid penetration and for studying how tumour cells survive in that nutrient-poor compartment.
Shares The brain: barrier and sanctuary, HER2-positive breast cancer, Melanoma, Non-small-cell lung cancer.
Shares The brain: barrier and sanctuary, HER2-positive breast cancer, Melanoma, Non-small-cell lung cancer.
Shares Blood-brain barrier (BBB), The brain: barrier and sanctuary.
Shares Patient-derived organoids, Lab models that fail to predict what happens in patients.
Shares Patient-derived organoids, Lab models that fail to predict what happens in patients.
Shares Patient-derived organoids, Lab models that fail to predict what happens in patients.
Shares Blood-brain barrier (BBB), The brain: barrier and sanctuary.
Shares Blood-brain barrier (BBB), The brain: barrier and sanctuary, HER2-positive breast cancer, Non-small-cell lung cancer.