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Pumping drugs slowly through fine tubes into a brain tumour can bypass the barrier, but the fluid often leaks away. Robotic placement and live scans would show where it actually goes.
Convection-enhanced delivery has repeatedly failed in trials, and post-hoc analyses attribute much of the failure to catheter placement and unmonitored backflow rather than to the drug. Robotic stereotactic placement, co-infused imaging tracers and intraoperative MRI make distribution measurable, and chronic implanted port systems permit repeat infusions on an outpatient basis.
Shares Michael Weller, Roger Stupp, The brain: barrier and sanctuary, Glioma & glioblastoma.
Shares Michael Weller, Roger Stupp, The brain: barrier and sanctuary, Failures are hidden.
Shares Blood-brain barrier (BBB), The brain: barrier and sanctuary, Glioma & glioblastoma.
Shares Roger Stupp, The brain: barrier and sanctuary, Glioma & glioblastoma.
Shares Blood-brain barrier (BBB), The brain: barrier and sanctuary, Failures are hidden.
Shares Robotic & minimally invasive surgery, MRI, Glioma & glioblastoma.
Shares Blood-brain barrier (BBB), The brain: barrier and sanctuary, Glioma & glioblastoma.
Shares Blood-brain barrier (BBB), The brain: barrier and sanctuary.