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Aggressive glioblastomas, sarcomas and gastric cancers keep amplified cancer genes such as EGFR, MYC, MDM2 and CDK4 on free-floating DNA circles (ecDNA) whose copy number rises and falls quickly, letting the tumour dial resistance up and down. Cells carrying ecDNA depend on CHK1, giving a first drug target.
ecDNA carries EGFR, MYC, MDM2, and CDK4 amplicons in glioblastoma, sarcoma, and gastric cancer, associates with shorter survival, and enables rapid drug resistance by copy-number fluctuation. The eDyNAmiC Cancer Grand Challenge team reported CHK1 dependence and transcription-replication conflicts in ecDNA+ cells (2024).
One of the most cited reviews Europe PMC returns for EGFR in Glioma & glioblastoma, so it is a natural first reading for anyone weighing the idea it is linked from. The record was linked automatically by title and abstract; read the abstract above and the paper itself before relying on any figure.
One idea page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One of the most cited reviews Europe PMC returns for EGFR in Glioma & glioblastoma, so it is a natural first reading for anyone weighing the idea it is linked from. The record was linked automatically by title and abstract; read the abstract above and the paper itself before relying on any figure.
One of the most cited reviews Europe PMC returns for EGFR in Gastric & gastro-oesophageal junction cancer, so it is a natural first reading for anyone weighing the idea it is linked from. The record was linked automatically by title and abstract; read the abstract above and the paper itself before relying on any figure.
Shares Stanford Health Care / Stanford Cancer Institute, Clonal evolution & minimal residual disease, EGFR, Liquid biopsy (ctDNA) and the tags mechanism, open-question.
Shares Chromosomal instability & aneuploidy, Stanford Health Care / Stanford Cancer Institute and the tags mechanism, open-question.
Shares Stanford Health Care / Stanford Cancer Institute, Glioma & glioblastoma and the tags mechanism, open-question.
Shares Clonal evolution & minimal residual disease, Cancer Research UK and the tags mechanism, open-question.
Shares Gastric & gastro-oesophageal junction cancer and the tags mechanism, open-question.
Shares Glioma & glioblastoma and the tags mechanism, open-question.
Shares Liquid biopsy (ctDNA) and the tags mechanism, open-question.
Shares the tags mechanism, open-question.