Loading
Injecting a dye that makes tumour glow so the surgeon can see exactly where to cut.
In fluorescence-guided surgery a tumour-selective fluorophore accumulates in the tumour and is imaged with near-infrared camera systems, so the surgeon can see disease that is invisible under white light. 5-ALA in glioma increases complete resection rates; pafolacianine (Cytalux) finds occult ovarian and lung lesions; pegulicianine (Lumisight, 2024) detects residual breast cancer in the lumpectomy cavity. The clinical payoff is fewer positive margins and re-operations. Targeted probes against EGFR, PSMA, and CEA are in phase 2-3 and would extend the approach to more tumour types. The limitation is millimetre depth penetration, so the dye shows surface disease and cannot see deep into tissue. The simple version is that a dye makes the tumour glow so the surgeon knows exactly where to cut.
A tumour-selective fluorophore accumulates in the tumour and is imaged with near-infrared camera systems.
A drink taken before brain surgery that makes high-grade glioma glow under blue light, letting surgeons remove more tumour safely.
An injected dye that makes ovarian and lung cancer deposits glow during surgery so surgeons can find lesions they would otherwise miss.
A cavity-imaging dye used during breast lumpectomy to spot leftover tumour before the operation ends, reducing second surgeries.
Query for this technology: (TITLE:"fluorescence-guided surgery" OR ABSTRACT:"fluorescence-guided surgery" OR TITLE:"fluorescence guided surgery" OR ABSTRACT:"fluorescence guided surgery" OR TITLE:"near-infrared fluorescence" OR ABSTRACT:"near-infrared fluorescence") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Fluorescence-guided surgery, not a curated reading list.
Shares An independent evaluation unit for surgical robots and AI, paid on evidence, Real-time margin assessment and image-guided surgery as the global standard, A pragmatic trial network for intraoperative margin tools, paid on margin reduction, Surgery and radiotherapy cure most, get least.
Shares An independent evaluation unit for surgical robots and AI, paid on evidence, Surgical robots: da Vinci, Hugo, Versius and single-port systems, Intraoperative fluorescence and Cerenkov imaging systems (SPY, Firefly, LumiSystem, LightPath), Surgery and radiotherapy cure most, get least.
Shares Karl Storz, SBI Pharmaceuticals.
Shares Targeted axillary dissection (MD Anderson prospective study), European Society of Surgical Oncology, Society of Surgical Oncology, Surgical robots: da Vinci, Hugo, Versius and single-port systems.
Shares Intraoperative MRI and CT, Surgical robots: da Vinci, Hugo, Versius and single-port systems, Intraoperative fluorescence and Cerenkov imaging systems (SPY, Firefly, LumiSystem, LightPath).
Shares An independent evaluation unit for surgical robots and AI, paid on evidence, A translation fund for academic surgical devices and radiotherapy technology, Surgery and radiotherapy cure most, get least.
Shares On Target Laboratories, Pafolacianine.
Shares 5-Aminolevulinic acid (oral, for glioma surgery), Extent of resection (RANO resect classes).