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Removing just the first lymph node a tumour drains to, instead of all of them, to check for spread.
Sentinel lymph node biopsy injects a tracer (radiocolloid, blue dye, ICG, or magnetic particles) at the tumour to identify the first draining node, which is removed and examined instead of clearing the whole nodal basin. It is standard in breast cancer and melanoma and replaced full node dissection for most patients after Z0011 and AMAROS showed that omitting completion dissection did not compromise outcomes. The main benefit is avoiding lymphoedema from full dissection. It is now being omitted entirely in low-risk breast cancer (SOUND, INSEMA trials), an example of surgical de-escalation driven by better systemic therapy and imaging. False negatives occur in roughly 5-10% of cases, which is the accepted trade-off. The simple version is that surgeons check the one node most likely to harbour spread rather than removing them all.
Tracer (radiocolloid, blue dye, ICG, magnetic) injected at tumour identifies draining node.
Hexaminolevulinate makes bladder tumours fluoresce red under blue light so the urologist can see and remove flat and tiny cancers that white-light cystoscopy misses.
Technetium sulfur colloid is the radioactive tracer injected around a breast cancer or melanoma before surgery so the surgeon can find the first lymph node the tumour drains to and remove only that node instead of the whole basin.
The purpose-built tracer for sentinel lymph node mapping in breast cancer, melanoma and oral cancer, replacing off-label sulfur colloid.
Query for this technology: (TITLE:"sentinel lymph node biopsy" OR ABSTRACT:"sentinel lymph node biopsy" OR TITLE:"sentinel node" OR ABSTRACT:"sentinel node") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Sentinel lymph node biopsy, not a curated reading list.
Shares ALMANAC (Axillary Lymphatic Mapping Against Nodal Axillary Clearance), INSEMA (Intergroup Sentinel Mamma), SOUND (Sentinel Node vs Observation After Axillary Ultra-Sound), IBCSG 23-01.
Shares ALMANAC (Axillary Lymphatic Mapping Against Nodal Axillary Clearance), IBCSG 23-01, Targeted axillary dissection, AMAROS (EORTC 10981-22023).
Shares Adenoid cystic carcinoma of the breast, Secretory carcinoma of the breast, Metaplastic breast carcinoma, Paget disease of the nipple.
Shares Adenoid cystic carcinoma of the breast, Secretory carcinoma of the breast, Metaplastic breast carcinoma, Paget disease of the nipple.
Shares FIRES & SENTOR (sentinel node mapping), Prizes for unpatentable surgical and radiotherapy techniques proven in trials, Keio University Hospital, European Society of Surgical Oncology.
Shares Early cervical cancer and fertility-sparing surgery, Sentinel node biopsy, POLE-ultramutated endometrial cancer, Uterine carcinosarcoma.
Shares Targeted axillary dissection (MD Anderson prospective study), Targeted axillary dissection, ACOSOG Z1071 (Alliance), ATNEC.
Shares Targeted axillary dissection, ACOSOG Z1071 (Alliance), ATNEC, NSABP Foundation.