{"entity":{"id":"chronotherapy","kind":"technology","name":"Chronotherapy: timing treatment to the body clock","aka":[],"tldr":"Giving the same drug at a different time of day, because the body clock changes how much damage it does and how well the immune system responds.","summary":"Retrospective series repeatedly report better outcomes when checkpoint inhibitors are infused earlier in the day, and chronomodulated chemotherapy has a long European history in colorectal cancer with mixed randomised results. The signal is confounded: patients infused late are often sicker or attend different clinics. Prospective randomised trials of infusion timing are small and ongoing, and nothing has changed practice.","status":"phase-2","asOf":"2026-09-08","links":[{"label":"ClinicalTrials.gov: time-of-day immunotherapy infusion","url":"https://clinicaltrials.gov/search?term=time%20of%20day%20immunotherapy%20infusion"}],"tags":["frontier","promising"],"related":[],"cancers":[],"sections":["chemotherapy","immunotherapy","supportive-care","nutrition-lifestyle"],"technologies":["cytotoxic-chemotherapy","checkpoint-inhibitor"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"principle":"Circadian variation in drug metabolism, DNA repair and immune-cell trafficking makes both toxicity and efficacy depend on time of day.","strengths":["Free: only scheduling changes","Applies across drug classes","Consistent direction across retrospective cohorts"],"limitations":["Retrospective data are heavily confounded","Randomised chronomodulated chemotherapy gave mixed results with sex differences","Clinic logistics make morning slots scarce"]},"route":"/technologies/chronotherapy/","neighbours":{"section":[{"id":"chemotherapy","kind":"section","name":"Chemotherapy","route":"/fronts/chemotherapy/"},{"id":"nutrition-lifestyle","kind":"section","name":"Diet, Exercise & Lifestyle","route":"/fronts/nutrition-lifestyle/"},{"id":"immunotherapy","kind":"section","name":"Immunotherapy","route":"/fronts/immunotherapy/"},{"id":"supportive-care","kind":"section","name":"Supportive Care & Survivorship","route":"/fronts/supportive-care/"}],"technology":[{"id":"cytotoxic-chemotherapy","kind":"technology","name":"Cytotoxic chemotherapy","route":"/technologies/cytotoxic-chemotherapy/"},{"id":"checkpoint-inhibitor","kind":"technology","name":"Immune checkpoint inhibitors","route":"/technologies/checkpoint-inhibitor/"},{"id":"sleep-circadian-interventions","kind":"technology","name":"Sleep and circadian interventions in cancer","route":"/technologies/sleep-circadian-interventions/"},{"id":"time-restricted-eating","kind":"technology","name":"Time-restricted eating in cancer prevention and survivorship","route":"/technologies/time-restricted-eating/"}],"roadmap":[{"id":"cure-paths","kind":"roadmap","name":"Paths to cures: interception, eradication, control","route":"/roadmaps/cure-paths/"},{"id":"frontier-2035","kind":"roadmap","name":"Radical oncology: what could change the war by 2035","route":"/roadmaps/frontier-2035/"}],"idea":[{"id":"idea-nl-sleep-circadian-survivorship-rct","kind":"idea","name":"Treat insomnia in survivors and measure whether the cancer notices","route":"/ideas/idea-nl-sleep-circadian-survivorship-rct/"}]}}