Loading
Giving the innate immune system a memory, so monocytes and NK cells respond harder the next time they meet a tumour.
BCG, the oldest immunotherapy, works partly by epigenetically reprogramming myeloid progenitors, an effect now called trained immunity. Beta-glucans and other agonists are being tested to induce the same state deliberately, alone or before checkpoint blockade. Evidence in cancer beyond intravesical BCG is early, and the same reprogramming can be immunosuppressive in the wrong context.
Epigenetic and metabolic rewiring of haematopoietic progenitors produces monocytes and NK cells with heightened effector responses lasting months.
Query for this technology: (TITLE:"Trained innate immunity" OR ABSTRACT:"Trained innate immunity") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Trained innate immunity, not a curated reading list.
Shares Paths to cures: interception, eradication, control, Radical oncology: what could change the war by 2035 and the tag frontier.
Shares Paths to cures: interception, eradication, control, Radical oncology: what could change the war by 2035 and the tag frontier.
Shares Cytokines & engineered cytokines, Immune checkpoint inhibitors and the tag frontier.
Shares Radical oncology: what could change the war by 2035 and the tag frontier.
Shares Radical oncology: what could change the war by 2035 and the tag frontier.
Shares Radical oncology: what could change the war by 2035 and the tag frontier.
Shares Paths to cures: interception, eradication, control, Radical oncology: what could change the war by 2035 and the tag frontier.
Shares Radical oncology: what could change the war by 2035 and the tag frontier.