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Hyperthermia heats tumours to 40-43 °C to make radiation and chemotherapy work better.
Hyperthermia heats tumours to 40-43 °C, which impairs DNA repair and increases perfusion and drug delivery, making radiation and chemotherapy more effective without adding their toxicity. Regional and deep hyperthermia improve outcomes with radiotherapy in cervical cancer, recurrent breast cancer, and soft-tissue sarcoma (EORTC 62961). Magnetic nanoparticle hyperthermia (NanoTherm) is approved in Europe for glioblastoma. Despite this evidence it is underused outside Germany and the Netherlands, because the equipment and expertise are scarce and the technique sits awkwardly between radiotherapy and medical oncology. The simple version is that warming a tumour makes standard treatments work better, and the main barrier is access rather than evidence.
Heat impairs DNA repair and increases perfusion and drug delivery.
Query for this technology: (TITLE:"hyperthermia" OR ABSTRACT:"hyperthermia") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma) AND (radiotherapy OR chemotherapy). Results are unfiltered search hits about Hyperthermia, not a curated reading list.
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