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Removing a bone or soft-tissue sarcoma while keeping the arm or leg, rebuilding with metal implants, bone grafts or growing prostheses in children.
Since the 1980s, >90% of extremity sarcomas are treated with limb-sparing resection plus radiotherapy (soft tissue) or chemotherapy (bone) with survival equal to amputation. Modular and expandable endoprostheses, allografts, rotationplasty, 3D-printed custom implants, and navigation-guided resection are current practice. Function and infection rates are the trade-offs.
Wide en-bloc resection with negative margins, reconstruction, and multimodal adjuvant therapy replace amputation.
Query for this technology: (TITLE:"Limb-salvage surgery and endoprosthetic reconstruction" OR ABSTRACT:"Limb-salvage surgery and endoprosthetic reconstruction") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Limb-salvage surgery and endoprosthetic reconstruction, not a curated reading list.
Shares Myxofibrosarcoma, Perivascular epithelioid cell tumour (PEComa), Malignant peripheral nerve sheath tumour (MPNST), Undifferentiated pleomorphic sarcoma (UPS).
Shares Myxofibrosarcoma, Undifferentiated pleomorphic sarcoma (UPS), Soft tissue sarcoma of the extremity (localised and advanced), Osteosarcoma.
Shares Alveolar soft part sarcoma, Chondrosarcoma, Epithelioid sarcoma, Osteosarcoma.
Shares Myxofibrosarcoma, Malignant peripheral nerve sheath tumour (MPNST), Undifferentiated pleomorphic sarcoma (UPS), Soft tissue sarcoma of the extremity (localised and advanced).
Shares Malignant peripheral nerve sheath tumour (MPNST), Undifferentiated pleomorphic sarcoma (UPS), Soft tissue sarcoma of the extremity (localised and advanced), Sarcomas (soft tissue, bone, GIST).
Shares Limb-salvage surgery, Isolated limb perfusion and infusion, Sarcomas (soft tissue, bone, GIST).
Shares Undifferentiated pleomorphic sarcoma (UPS), Ewing sarcoma, Osteosarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Alveolar soft part sarcoma, Malignant peripheral nerve sheath tumour (MPNST), Epithelioid sarcoma, Undifferentiated pleomorphic sarcoma (UPS).