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The FNCLCC grade is a 1-to-3 score for soft-tissue sarcomas based on how abnormal, how fast-dividing, and how much dead tissue the tumour shows; grade drives whether chemotherapy is considered.
The FNCLCC grade is the French Federation of Cancer Centres system for grading soft-tissue sarcoma, described by Trojani and colleagues in 1984. A pathologist scores tumour differentiation, mitotic count and necrosis and sums them to a grade of 1 to 3, so the grade captures how abnormal the cells look, how fast they divide and how much dead tissue the tumour contains. It matters because grade 3, together with size above 5 cm and deep location, defines high-risk disease eligible for neoadjuvant chemotherapy, as in the ISG-STS 1001 trial, and feeds nomogram-based prediction tools such as Sarculator. Readers meet the term in the sarcoma record covering soft tissue, bone and GIST, in the osteosarcoma record, and in the bottleneck on rare and paediatric cancers without markets.
Bone sarcomas favour the fast-growing ends of long bones (osteosarcoma) or the shaft (Ewing), soft tissue sarcomas the deep muscle compartments; spread is through the blood to the lungs, rarely via lymph nodes.
Lymph node spread is rare (except epithelioid, synovial, clear cell and rhabdomyosarcoma); sarcomas go through the blood to the lungs.
Same organ: Adamantinoma of bone, Dedifferentiated chordoma, Poorly differentiated chordoma (SMARCB1-deficient), Desmoplastic small round cell tumour, Leiomyosarcoma, Liposarcoma, Synovial sarcoma, Osteosarcoma, Ewing sarcoma, Rhabdomyosarcoma, Chordoma, Desmoid tumour, Tenosynovial giant cell tumour (TGCT), Epithelioid sarcoma, Vascular tumours (angiosarcoma, epithelioid haemangioendothelioma, kaposiform haemangioendothelioma), Chondrosarcoma, Angiosarcoma, Undifferentiated pleomorphic sarcoma (UPS), Myxofibrosarcoma, Alveolar soft part sarcoma, Perivascular epithelioid cell tumour (PEComa), Epithelioid haemangioendothelioma, Malignant peripheral nerve sheath tumour (MPNST), Retroperitoneal sarcoma, Soft tissue sarcoma of the extremity (localised and advanced)
Showing the organ this term concerns: Sarcomas (soft tissue, bone, GIST).
Shares ISG-STS 1001, Undifferentiated pleomorphic sarcoma (UPS), Soft tissue sarcoma of the extremity (localised and advanced), Sarcomas (soft tissue, bone, GIST).
Shares ISG-STS 1001, Soft tissue sarcoma of the extremity (localised and advanced), Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST).
Shares ISG-STS 1001, Undifferentiated pleomorphic sarcoma (UPS), Soft tissue sarcoma of the extremity (localised and advanced).
Shares Myxofibrosarcoma, Retroperitoneal sarcoma, Undifferentiated pleomorphic sarcoma (UPS), Soft tissue sarcoma of the extremity (localised and advanced).
Shares Retroperitoneal sarcoma, Soft tissue sarcoma of the extremity (localised and advanced), Sarcomas (soft tissue, bone, GIST).
Shares Myxofibrosarcoma, Undifferentiated pleomorphic sarcoma (UPS), Soft tissue sarcoma of the extremity (localised and advanced).
Shares Myxofibrosarcoma, Undifferentiated pleomorphic sarcoma (UPS), Soft tissue sarcoma of the extremity (localised and advanced), Osteosarcoma.
Shares Undifferentiated pleomorphic sarcoma (UPS), Osteosarcoma, Sarcomas (soft tissue, bone, GIST).