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Adding ifosfamide to doxorubicin shrank more sarcomas and delayed progression but did not significantly lengthen life, so doxorubicin alone stayed the standard unless a tumour needs to shrink.
EORTC 62012 randomised 455 patients with previously untreated advanced soft tissue sarcoma to doxorubicin 75 mg/m2 alone or the same dose with ifosfamide 10 g/m2 and growth factor support. The combination improved objective response and progression-free survival at the cost of much greater haematological toxicity, but the primary endpoint of overall survival was not significantly improved. Published in Lancet Oncology in 2014, it is the reference for the first-line choice in advanced sarcoma: single-agent doxorubicin for palliation, the combination when response is needed, for example to make a tumour operable or relieve symptoms.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
455 enrolled.
Shares EORTC 62012: doxorubicin alone versus intensified doxorubicin plus ifosfamide for first-line treatment of advanced soft tissue sarcoma, Undifferentiated pleomorphic sarcoma (UPS), Soft tissue sarcoma of the extremity (localised and advanced), Ifosfamide and the tag subtype-page.
Shares Soft tissue sarcoma of the extremity (localised and advanced), Doxorubicin, Sarcomas (soft tissue, bone, GIST), Cytotoxic chemotherapy and the tag subtype-page.
Shares EORTC 62012: doxorubicin alone versus intensified doxorubicin plus ifosfamide for first-line treatment of advanced soft tissue sarcoma, Malignant peripheral nerve sheath tumour (MPNST), Undifferentiated pleomorphic sarcoma (UPS), Soft tissue sarcoma of the extremity (localised and advanced) and the tag subtype-page.
Shares EORTC 62012: doxorubicin alone versus intensified doxorubicin plus ifosfamide for first-line treatment of advanced soft tissue sarcoma, Undifferentiated pleomorphic sarcoma (UPS), Soft tissue sarcoma of the extremity (localised and advanced), Ifosfamide and the tag subtype-page.
Shares EORTC, Sarcomas (soft tissue, bone, GIST) and the tag subtype-page.
Shares Undifferentiated pleomorphic sarcoma (UPS), Soft tissue sarcoma of the extremity (localised and advanced), Ifosfamide, Doxorubicin and the tag subtype-page.
Shares Soft tissue sarcoma of the extremity (localised and advanced), Ifosfamide, Doxorubicin, Sarcomas (soft tissue, bone, GIST) and the tag subtype-page.
Shares Sarcomas (soft tissue, bone, GIST), Cytotoxic chemotherapy and the tag subtype-page.