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In leiomyosarcoma, adding trabectedin to doxorubicin roughly doubled the time the disease stayed controlled, the first randomised first-line gain in this sarcoma in decades.
LMS-04 randomised 150 patients with metastatic or unresectable uterine or soft tissue leiomyosarcoma to six cycles of doxorubicin plus trabectedin followed by trabectedin maintenance, or doxorubicin alone. Median progression-free survival was 12.2 months with the combination versus 6.2 months with doxorubicin (hazard ratio 0.41), with more haematological toxicity, and later follow-up also reported improved overall survival. Published in Lancet Oncology in 2022, it established doxorubicin plus trabectedin as a first-line standard for fit patients with leiomyosarcoma and as the model for histology-specific sarcoma trials.
Numbers are from the trial as recorded here; see the source links in the table below. This is orientation, not medical advice: ask your team how closely the trial population matches you.
Shares Retroperitoneal sarcoma, Leiomyosarcoma, Sarcomas (soft tissue, bone, GIST) and the tag subtype-page.
Shares Soft tissue sarcoma of the extremity (localised and advanced), Doxorubicin, Sarcomas (soft tissue, bone, GIST), Cytotoxic chemotherapy and the tag subtype-page.
Shares French Sarcoma Group, Sarcomas (soft tissue, bone, GIST), Cytotoxic chemotherapy and the tag subtype-page.
Shares Trabectedin, Retroperitoneal sarcoma, Leiomyosarcoma, Soft tissue sarcoma of the extremity (localised and advanced) and the tag subtype-page.
Shares Trabectedin, Retroperitoneal sarcoma, Leiomyosarcoma, Soft tissue sarcoma of the extremity (localised and advanced) and the tag subtype-page.
Shares Leiomyosarcoma, Soft tissue sarcoma of the extremity (localised and advanced), Doxorubicin, Sarcomas (soft tissue, bone, GIST) and the tag subtype-page.
Shares Retroperitoneal sarcoma, Uterine sarcoma, Doxorubicin, Sarcomas (soft tissue, bone, GIST) and the tag subtype-page.
Shares Trabectedin, Leiomyosarcoma, Soft tissue sarcoma of the extremity (localised and advanced), Doxorubicin and the tag subtype-page.