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Beromun is a recombinant form of the immune protein TNF-alpha, pumped with the chemotherapy melphalan through the isolated blood supply of an arm or leg to shrink soft-tissue sarcomas so that the limb can be saved rather than amputated.
Tasonermin was authorised by the European Commission in April 1999 as an adjunct to surgery for irresectable soft-tissue sarcoma of the limbs, with melphalan via mild hyperthermic isolated limb perfusion, to prevent or delay amputation or for palliation, on multicentre European studies in which the majority of patients achieved limb salvage. Systemic TNF-alpha is far too toxic to give intravenously, so the drug exists only for this surgical technique performed in a small number of specialist centres. It is not approved in the US. Regional toxicity (limb oedema, skin reactions, neuropathy) and, if leakage into the systemic circulation occurs, shock are the main risks; the same approach is used for in-transit melanoma.
Backbone ribbon from PDB 1TNF. RCSB PDB 1TNF. The ribbon widens where the chain is folded into a regular pattern and narrows where it is a loose loop.
Recombinant human TNF-alpha delivered with melphalan under mild hyperthermia to an isolated limb circulation; disrupts tumour vasculature and increases melphalan penetration, causing haemorrhagic necrosis of the sarcoma.
1.Tasonermin binds its target.
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| Region | Year | Indication |
|---|---|---|
| EU | 1999 | Irresectable soft-tissue sarcoma of the limbs with melphalan via isolated limb perfusion, as an adjunct to surgery or for palliation |
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Query for this drug: (TITLE:"Tasonermin" OR ABSTRACT:"Tasonermin" OR TITLE:"Beromun" OR ABSTRACT:"Beromun" OR TITLE:"Recombinant TNF-alpha-1a" OR ABSTRACT:"Recombinant TNF-alpha-1a" OR TITLE:"rTNF-alpha" OR ABSTRACT:"rTNF-alpha") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Tasonermin, not a curated reading list.
Shares Cytokines & engineered cytokines, Sarcomas (soft tissue, bone, GIST), Melanoma.
Shares Limb-salvage surgery, Isolated limb perfusion and infusion, Sarcomas (soft tissue, bone, GIST).
Shares Cytokines & engineered cytokines, Sarcomas (soft tissue, bone, GIST), Melanoma.
Shares Melphalan (including hepatic delivery system), Melanoma.
Shares Limb-salvage surgery, Isolated limb perfusion and infusion, Sarcomas (soft tissue, bone, GIST).
Shares Cytokines & engineered cytokines, Melanoma.
Shares Limb-salvage surgery, Sarcomas (soft tissue, bone, GIST), Melanoma.
Shares Cytokines & engineered cytokines, Melanoma.