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Instead of one uniform dose, the plan gives more to the parts of the tumour that imaging says are most resistant, such as hypoxic or highly active regions on PET.
Functional imaging (FDG PET, hypoxia PET, diffusion and perfusion MRI) shows that tumours are not uniform. Dose painting escalates the dose to the imaging-defined resistant subvolume while holding the rest at standard levels, either by contours or voxel by voxel. Trials in head and neck cancer and glioblastoma have shown feasibility and some local-control signals; biology-guided radiotherapy systems that use PET emissions in real time to steer the beam (RefleXion) extend the idea to tracking. The limits are the reliability of the imaging signal and the risk of toxicity in the boosted region.
Imaging biomarkers define a resistant subvolume that receives a higher dose, matching dose to biology rather than to anatomy alone.
Query for this technology: (TITLE:"Dose painting and biologically guided radiotherapy" OR ABSTRACT:"Dose painting and biologically guided radiotherapy") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Dose painting and biologically guided radiotherapy, not a curated reading list.
Shares Tumour hypoxia, PET (positron emission tomography), Glioma & glioblastoma, Head and neck squamous cell carcinoma and the tag radiation-wave1.
Shares Adaptive radiotherapy (online replanning), IMRT / IGRT (modern external beam) and the tag radiation-wave1.
Shares Adaptive radiotherapy (online replanning) and the tag radiation-wave1.
Shares Adaptive radiotherapy (online replanning), IMRT / IGRT (modern external beam) and the tag radiation-wave1.
Shares Head and neck squamous cell carcinoma, IMRT / IGRT (modern external beam) and the tag radiation-wave1.
Shares Tumour hypoxia, Glioma & glioblastoma, Head and neck squamous cell carcinoma, IMRT / IGRT (modern external beam) and the tag radiation-wave1.
Shares Head and neck squamous cell carcinoma, IMRT / IGRT (modern external beam) and the tag radiation-wave1.
Shares IMRT / IGRT (modern external beam) and the tag radiation-wave1.