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A scan that shows where a radioactive tracer accumulates, so it images what tumours are doing rather than what they look like.
Positron emission tomography detects the paired 511 keV gamma photons produced when a positron from a radioactive tracer annihilates with an electron; coincidence detection localises the source and the standardised uptake value (SUV) quantifies it. Isotopes such as 18F, 68Ga, 89Zr and 64Cu are attached to a targeting molecule, and the tracer determines what is measured: glucose metabolism (FDG), receptor expression (PSMA, SSTR, TROP2, HER2), stroma (FAP), immune cells (CD8) or DNA repair (PARP). In clinical use since 1975, it is almost always combined with CT or MRI for anatomic reference. Its strengths are whole-body biology in one quantitative scan and the fact that any target with a ligand can in principle be imaged. Resolution of about 4 mm and tracer supply and cost are the main limitations. PET images what tumours are doing rather than what they look like.
Positron-emitting isotopes (18F, 68Ga, 89Zr, 64Cu) attached to a targeting molecule; coincidence detection of 511 keV photons; standardised uptake value (SUV) quantifies uptake.
Dependencies are what this technology cannot be delivered without: manufacturing steps, instruments, software, upstream methods. See its full chain on the map.
Choline C-11 was the first PET tracer approved in the United States, in 2012, to find where prostate cancer has come back when PSA rises after treatment; PSMA tracers have now largely replaced it.
Florastamin is FutureChem's fluorine-18 PSMA PET tracer from South Korea, in phase 3 trials for staging high-risk and recurrent prostate cancer alongside the established PSMA agents.
Fluciclovine F-18 was the first PET tracer approved for finding recurrent prostate cancer after treatment (2016), and has been largely superseded since 2020 by PSMA PET.
The radioactive sugar used in almost every cancer PET scan, approved in the 1990s and made fresh each day by regional cyclotrons.
A PET scan that shows which breast cancer deposits still have oestrogen receptors, helping decide whether hormone therapy will work when biopsy is impractical.
PSMA-1007 is a fluorine-18 PSMA PET tracer from ABX in Germany, widely used in Europe for prostate cancer staging because little of it reaches the bladder, and in a phase 3 trial registered by its maker.
Zirconium-89 girentuximab is Telix's PET scan that tells whether a kidney mass is clear cell renal cell carcinoma without a biopsy; the phase 3 ZIRCON trial met its endpoints in 2023 and the product is under regulatory review.
Query for this technology: (TITLE:"positron emission tomography" OR ABSTRACT:"positron emission tomography") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PET (positron emission tomography), not a curated reading list.
Shares PET/MRI, Nuclear medicine and total-body PET hardware, Fluoroestradiol F-18 (FES PET), CT, MRI and PET scanner manufacturing.
Shares PET/MRI, Nuclear medicine and total-body PET hardware, Total-body PET for screening and ultra-low-dose imaging, CT, MRI and PET scanner manufacturing.
Shares PET/MRI, Nuclear medicine and total-body PET hardware, Total-body PET for screening and ultra-low-dose imaging, CT, MRI and PET scanner manufacturing.
Shares GRPR (gastrin-releasing peptide receptor), Evergreen Theragnostics, Wolfgang A. Weber, Johannes Czernin.
Shares Wolfgang A. Weber, PET/MRI, FAPI PET, PSMA PET.
Shares PSMA-PET to Guide Prostatectomy, PSMA-1007 F-18, Johannes Czernin, Florastamin F-18.
Shares Zirconium-89 girentuximab, CAIX PET (89Zr-girentuximab), PET tracer manufacturing and distribution, Cyclotron isotope production (F-18, Ga-68, Cu-64, Zr-89, At-211).
Shares Medical cyclotrons, hot cells, and synthesis modules, PET tracer manufacturing and distribution, Cyclotron isotope production (F-18, Ga-68, Cu-64, Zr-89, At-211), Somatostatin receptor PET (68Ga/64Cu-DOTATATE).
Open-source projects that implement or serve this technology, from OnCo's own catalogue: licence and last activity as the repository reported them on the day of the fetch. Listing is not endorsement; check the licence before reuse and the validation before clinical use.
The original GATE code base for imaging and dosimetry simulations.
The OpenGATE collaboration's Geant4-based simulation platform for PET, SPECT, CT and radiotherapy dosimetry, now in Python.
Open-source software, hardware and data projects catalogued by a third party, the Open Medical Registry, that bear on this technology. Listing is not endorsement; check each project's own licence and validation before clinical use.
Tiny library for calculating Standardized Uptake Value for Nuclear Medicine (i.e.
Official public repository of Gate
A 3D lesion segmentation method on whole-body PET images including automated quality control.
From the Open Medical Registry (openmedical.sh), an MIT-licensed catalogue of open-source medicine. Blurbs are one line from each registry record; every project keeps its own licence.