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Robert Mach invented the PARP PET tracer FluorThanatrace that images DNA repair capacity in tumours.
Robert H. Mach is the Britton Chance Professor of Radiology and Director of PET Radiochemistry at the Abramson Cancer Center, University of Pennsylvania. He is a radiochemist known for inventing the PARP PET tracer fluorine-18 FluorThanatrace, which images DNA repair capacity in tumours, alongside other tracers for imaging drug targets. His selected paper reports FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancer. His laboratory's tracers enable PARP-inhibitor patient selection studies and molecular imaging with PET.
| Title | Journal | Year |
|---|---|---|
| [18F]FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancer | American Journal of Nuclear Medicine and Molecular Imaging | 2018 |