{"entity":{"id":"robert-mach","kind":"person","name":"Robert H. Mach","aka":[],"tldr":"Robert Mach invented the PARP PET tracer FluorThanatrace that images DNA repair capacity in tumours.","summary":"Robert H. Mach is the Britton Chance Professor of Radiology and Director of PET Radiochemistry at the Abramson Cancer Center, University of Pennsylvania. He is a radiochemist known for inventing the PARP PET tracer fluorine-18 FluorThanatrace, which images DNA repair capacity in tumours, alongside other tracers for imaging drug targets. His selected paper reports FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancer. His laboratory's tracers enable PARP-inhibitor patient selection studies and molecular imaging with PET.","asOf":"2026-09-08","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Mach%20RH%5BAuthor%5D"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":["parp-pet","pet"],"targets":["parp"],"drugs":[],"companies":[],"institutions":["penn-abramson"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Britton Chance Professor of Radiology; Director, PET Radiochemistry","institutionId":"penn-abramson","specialisms":["Radiochemistry","PARP PET","Molecular imaging"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Mach%20RH%5BAuthor%5D"}],"papers":[{"title":"[18F]FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancer","journal":"American Journal of Nuclear Medicine and Molecular Imaging","year":2018}],"orcid":"0000-0002-7645-2869"},"route":"/people/robert-mach/","neighbours":{"technology":[{"id":"parp-pet","kind":"technology","name":"PARP PET","route":"/technologies/parp-pet/"},{"id":"pet","kind":"technology","name":"PET (positron emission tomography)","route":"/technologies/pet/"}],"target":[{"id":"parp","kind":"target","name":"PARP","route":"/targets/parp/"}],"institution":[{"id":"penn-abramson","kind":"institution","name":"Abramson Cancer Center, University of Pennsylvania","route":"/institutions/penn-abramson/"}]}}