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FAPI PET is a PET scan that lights up the scaffolding around almost any solid tumour, including cancers the standard sugar scan misses.
Quinoline-based FAP inhibitors (FAPI-04, FAPI-46, FAPI-74) labelled with 68Ga or 18F image cancer-associated fibroblasts. Superior to FDG in pancreatic, gastric, HCC, and peritoneal disease in head-to-head series. Registrational trials for 68Ga-FAPI-46 and 18F-FAPI-74 (Sofie) are underway. Pairs with FAP-targeted radioligands.
Small molecule binds FAP on stromal fibroblasts; rapid uptake, low background, minimal brain and liver signal.
A FAP-targeted theranostic pair: one version images almost any solid tumour, the other treats it with radiation.
Query for this technology: (TITLE:"FAPI PET" OR ABSTRACT:"FAPI PET" OR TITLE:"FAP inhibitor PET" OR ABSTRACT:"FAP inhibitor PET" OR TITLE:"68Ga-FAPI" OR ABSTRACT:"68Ga-FAPI" OR TITLE:"fibroblast activation protein PET" OR ABSTRACT:"fibroblast activation protein PET"). Results are unfiltered search hits about FAPI PET, not a curated reading list.
Shares Cancer-associated fibroblasts (CAFs), Reprogramme the stroma rather than remove it: second-generation stromal trials with a stromal biomarker and a survival endpoint, Desmoplasia (tumour stroma), FAP.
Shares Curanosticum Wiesbaden-Frankfurt, A Study of 177Lu-FAP-2286 in Advanced Solid Tumors, An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC., Wolfgang A. Weber.
Shares Cancer-associated fibroblasts (CAFs), Reprogramme the stroma rather than remove it: second-generation stromal trials with a stromal biomarker and a survival endpoint, Desmoplasia (tumour stroma), Fibroblast activation, desmoplasia & matrix stiffness.
Shares Postgraduate Institute of Medical Education and Research, Chandigarh, Uwe Haberkorn, Ken Herrmann, When the blood test is positive, hunt for the lesion with sensitive imaging.
Shares Invasion: proteases, adhesion & the invasive front, Desmoplasia (tumour stroma), FAP, Fibroblast activation, desmoplasia & matrix stiffness.
Shares What actually holds T cells at the tumour border?, Cancer-associated fibroblasts (CAFs), Reprogramme the stroma rather than remove it: second-generation stromal trials with a stromal biomarker and a survival endpoint, Invasion: proteases, adhesion & the invasive front.
Shares Postgraduate Institute of Medical Education and Research, Chandigarh, Uwe Haberkorn, Ken Herrmann, University Hospital Düsseldorf / CIO Düsseldorf.
Shares Shaoli Song, Molecular imaging roadmap: FDG → PSMA → FAP → antigen and immune PET, FES PET (oestrogen receptor imaging), PET (positron emission tomography).