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Trials
A Study of 177Lu-FAP-2286 in Advanced Solid Tumors

trialsTrialRecruiting

A Study of 177Lu-FAP-2286 in Advanced Solid Tumors

A phase 1/2 trial of FAP-2286 (177Lu / 68Ga) in advanced solid tumours, run by Novartis Pharmaceuticals, now recruiting.

Also called: LuMIERE

Overview Connected5

Overview

A Study of 177Lu-FAP-2286 in Advanced Solid Tumors is a phase 1/2 interventional study registered as NCT04939610 by Novartis Pharmaceuticals, with 222 participants planned, started 2021-07-30 and due to reach its primary completion in 2027-12-31. Interventions recorded: 68Ga-FAP-2286 and 177Lu-FAP-2286.

Setting

LuMIERE: A Phase 1/2, Multicenter, Open-label, Non-randomized Study to Investigate Safety and Tolerability, Pharmacokinetics, Dosimetry, and Preliminary Activity of 177Lu-FAP-2286 in Patients With an Advanced Solid Tumor

Phase

Phase 1/2

Sponsor

Novartis Pharmaceuticals

Registry

Started

2021-07-30

Enrolled

222 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

technologies

FAPI PET Radioligand therapy (beta emitters)

drugs

Phase 2Theranostic pair (peptide radioligand)

FAP-2286 (177Lu / 68Ga)

companies

Advanced Accelerator Applications (Novartis)

Evidence strength20/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
222 enrolled+12
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT04939610

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Technologies

FAPI PET
Radioligand therapy (beta emitters)

Products

FAP-2286 (177Lu / 68Ga)

Companies

Advanced Accelerator Applications (Novartis)

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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MCP server: npx -y onco-mcp, tools search, get_entity, list_kind, ask, context, compare. This record is get_entity or context with id nct04939610.

WebMCP tools registered on this page: onco_search, onco_get_entity.